Gene name:
Map2k1 (Mek1;Prkmk1) ;
Protein name:
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1;MAPKK 1) ;
Alternative:
MAPK/ERK kinase 1 (MEK 1) ;ERK activator kinase 1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with MORG1 (By similarity). Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14. Interacts with ARRB2. Interacts with VRK2.
Function:
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
Subcellular Location:
N/A
Protein Attributes:
50:
MPKKKPTPIQ | LNPAPDGSAV | NGTSSAETNL | EALQKKLEEL | ELDEQQRKRL |
100:
EAFLTQKQKV | GELKDDDFEK | ISELGAGNGG | VVFKVSHKPS | GLVMARKLIH |
150:
LEIKPAIRNQ | IIRELQVLHE | CNSPYIVGFY | GAFYSDGEIS | ICMEHMDGGS |
200:
LDQVLKKAGR | IPEQILGKVS | IAVIKGLTYL | REKHKIMHRD | VKPSNILVNS |
250:
RGEIKLCDFG | VSGQLIDSMA | NSFVGTRSYM | SPERLQGTHY | SVQSDIWSMG |
300:
LSLVEMAVGR | YPIPPPDAKE | LELLFGCQVE | GDAAETPPRP | RTPGRPLSSY |
350:
GMDSRPPMAI | FELLDYIVNE | PPPKLPSGVF | SLEFQDFVNK | CLIKNPAERA |
393:
DLKQLMVHAF | IKRSDAEEVD | FAGWLCSTIG | LNQPSTPTHA | ASI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Rabbit
ELISA Kit for Rat MAP kinase kinase 1
ELISA Kit for Rat MAP kinase kinase 1
ELISA Kit for Rat MAP kinase kinase 1
ELISA Kit for Rat MAP kinase kinase 1
CLIA Kit for Rat MAP kinase kinase 1
CLIA Kit for Rat MAP kinase kinase 1
CLIA Kit for Rat MAP kinase kinase 1
CLIA Kit for Rat MAP kinase kinase 1
Polyclonal Antibody for Rat MAP kinase kinase 1
Polyclonal Antibody for Rat MAP kinase kinase 1
Polyclonal Antibody for Rat MAP kinase kinase 1
Polyclonal Antibody for Rat MAP kinase kinase 1
Monoclonal Antibody for Rat MAP kinase kinase 1
Monoclonal Antibody for Rat MAP kinase kinase 1
Monoclonal Antibody for Rat MAP kinase kinase 1
Monoclonal Antibody for Rat MAP kinase kinase 1
Protein for Rat MAP kinase kinase 1
Protein for Rat MAP kinase kinase 1
Protein for Rat MAP kinase kinase 1
Protein for Rat MAP kinase kinase 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Kidney .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
strain :
Sprague-Dawley .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Thymus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 206-227; 270-291 AND 325-340;IDENTIFICATION BY MASS SPECTROMETRY
strain :
Sprague-Dawley .
tissue :
Hippocampus .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAIN;INTERACTION WITH RAF1;ENZYME REGULATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH LAMTOR3;ENZYME REGULATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION;FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ARRB2
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-298;ENZYME REGULATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-292 AND SER-298;INTERACTION WITH MAPK1/ERK2;ENZYME REGULATION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION OF THE MAPK/ERK PATHWAY
13.
"Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector."
Willard F.S.
,
Willard M.D.
,
Kimple A.J.
,
Soundararajan M.
,
Oestreich E.A.
,
Li X.
,
Sowa N.A.
,
Kimple R.J.
,
Doyle D.A.
,
Der C.J.
,
Zylka M.J.
,
Snider W.D.
,
Siderovski D.P.
PLoS ONE4:E4884-E4884(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN A COMPLEX WITH BRAF; HRAS; MAPK3 AND RGS14
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ENZYME REGULATION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION